Jarrow Alpha Lipoic Sustain (ALA) 300mg, Biotin 333mcg 60 Tab

What does Alpha Lipoic Sustain® 300 do?

Alpha Lipoic Sustain® 300 is in a bilayer Quick Release/Sustained Release format to maximize blood levels and to minimize gastric irritation and blood sugar fluctuations.* Alpha Lipoic Acid is a unique lipid and water soluble antioxidant that is a cofactor in energy production, helping to regulate glucose metabolism.* ALA also promotes the synthesis of glutathione.* Biotin is added for optimum ALA activity.*

The advanced bilayer technology combines 1/3 Quick Release and 2/3 Sustained Release formats to both immediately raise and to maintain blood levels over a longer period of time.*

Who Can Benefit From this Product?

Useful for anyone who seeks prolonged universal antioxidant protection throughout the body. Those looking to modulate carbohydrate levels and athletes may benefit especially.*

What Distinguishes this Product?

• Pharmaceutical Grade Alpha Lipoic Acid
• Bilayer Release Technology: 1/3 Quick, 2/3 Sustained Release
• The Universal Antioxidant + Biotin

How Does Each Active Ingredient Function in this Product?

Alpha Lipoic Acid: A powerful, universal antioxidant; essential for energy production and carbohydrate metabolism.*

Biotin (Vitamin B7): Among a multitude of roles, it is a cofactor necessary in the metabolism of fats and amino acids. It has been added to this formula to prevent biotin deficiency that may accompany long-term ALA use.*

Alpha Lipoic Sustain ®

What is Alpha Lipoic Acid?
Alpha lipoic acid (aka ALA, lipoate, thioctic acid, dihydrolipoic acid) is an antioxidant and co-factor in glycolysis. Glycolysis is the initial process in most of the body’s pathways to breakdown glucose into useful forms of energy. Though critical to oxygen utilizing life, ALA is not a vitamin because it can be synthesized from essential fatty acids and the amino acid L-cysteine. However, no food is rich enough to serve as a good source.

Chemically, ALA has two juxtaposed sulfur atoms. When oxidized, the two sulfurs bond together (disulfide form). When reduced to dihydrolipoic acid, each sulfur atom attaches to hydrogen (thiol form). ALA’s antioxidant chemistry is similar to glutathione, another sulfur-containing molecule and the most abundant antioxidant inside cells.

The Universal Antioxidant
ALA is reduced to its active form, dihydrolipoic acid, inside cells as the body needs it and is able to do so. The enzyme responsible for this, dihydrolipoamide dehydrogenase (LipHD), preferentially reduces the R-enantiomer of lipoic acid; this is why the R form is often considered the only biologically relevant form. However this may not be entirely accurate. Like vitamin C, ALA functions in water-based phases such as blood. However, like vitamin E, it also protects fatty tissues and membranes. ALA quenches free radicals— like hydroxyl, singlet-oxygen, and peroxynitrite—in both water and lipid phases, and protects against lipid peroxidation. It deactivates an unusually wide array of cell-damaging free radicals in many bodily systems.

Recycler Built for Two
ALA also enhances the potency of other antioxidants in both waterbased (blood, cytosol) and lipid (membrane, blood fat) compartments. It recycles vitamin C directly and vitamin E indirectly in a unique and significant capacity, often preventing the symptoms of deficiency of these two critical vitamins.*

Importantly, ALA increases glutathione levels in cells, in part by facilitating L-cysteine availability. It maintains the ratio of reduced-tooxidized coenzyme Q10, which impacts mitochondrial health and energy production.*

Blood Sugar Metabolism and Muscular Energy
Perhaps the most significant function of ALA is its important role in energy production from carbohydrates, participating in the multi-enzyme process on many levels. ALA stimulates insulin activity, reduces insulin resistance, and enhances glucose burning in obese laboratory animals. Humans with diabetes show a ~50% increase in glucose consumption. This also has implications for athletes and the overweight. Muscle activity requires efficient sugar metabolism. Similar improvements in sugar disposal occurred in brain tissue.

Alpha-lipoic acid is currently being studied for many age-related conditions, including heart and vascular health, sugar balance, neurological function, immune function, as well as fatigue and muscle strength. There is much protective promise in this powerful, broadspectrum
antioxidant.*

Special Delivery Requirements—Maximum Benefits
Jarrow Formulas® Alpha Lipoic Sustain® 300 is a bilayer Quick Release/Sustained Release ALA formulation. It maximizes blood levels while minimizing gastric irritation and blood sugar fluctuations.* Onethird of the ALA is releases rapidly and two-thirds releases slowly over time. This raises blood levels quickly while sustaining them.* ALA does not accumulate in tissues, so it has no toxicity in suggested amounts. With wide distribution throughout the body, it is used in many ways. ALA finds particular utility in the eyes and brain, with neuroprotective and possibly cognitive-enhancing effects, especially in combination with acetyl-L-carnitine.* It also has potential to reduce mercury retention.*

Protection is highly dependent upon the dosing regimen. ALA is rapidly cleared from blood by the liver, so it is best supplemented in multiple, divided doses. Clinical studies typically employ 300 mg taken twice daily. Pharmaceutically designed Alpha Lipoic Sustain 300 keeps ALA in circulation for much longer periods than the usual tablet or capsule delivery. Sustained release may also help avoid stomach irritation experienced by sensitive individuals.*

The Importance of Biotin
Since biotin and ALA are similar, and transported by the same mechanism, elevated dietary ALA can interfere with biotin absorption and coenzyme functions. To protect against biotin deficiency, Alpha Lipoic Sustain 300 contains over 100% of the recommended daily allowance for biotin.

Size: 60 Tabs

Suggested Usage

Take 1 to 2 tablets per day with meals, or as directed by your qualified health care consultant.

NOTE: If you have a medical condition (especially diabetes or being treated for glucose control), are pregnant, lactating, or trying to conceive, are under the age of 18, or are taking medications (especially for glucose control), consult your health care practitioner before using this product.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.