Jarrow SAM-e 200, 60 Cap

What does SAM-e 200 do?

Jarrow FORMULAS® pharmaceutical grade, stabilized SAM-e 200 provides a full 200 mg SAM-e (net yield) from 400 mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow FORMULAS® SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.SAM-e has been clinically shown to have the following benefits:

Joint Strength

SAM-e supports the production of healthy connective tissue through transulfuration.  In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.*

Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component oflecithin).*

Longevity

Methylation of DNA appears to be important in the suppression of errors in   DNA replication. Demethylation of DNA is considered a contributor to the aging process.* Proper methylation through substances such as SAM-e positively influences longevity.*

Liver

SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*

Who Can Benefit from this Product?

Older individuals are less able to produce adequate SAM-e, which can lead to a decline in health on many levels. It is beneficial for those wanting to optimize cognitive function, mood, energy levels, liver and joint health.*

What Distinguishes this Product?

• Jarrow Formulas SAM-e is an active form (contains more of the active S,S form) of this important substance.
• Jarrow Formulas SAM-e is made naturally by fermentation.
• Jarrow Formulas SAM-e is specially processed, without solvents, to preserve the highest active level available.
• To preserve activity, Jarrow Formulas SAM-e is manufactured under low temperature and low humidity, and the tablet is enteric coated and blister-packed.

How Does Each Active Ingredient Function in this Product?

SAM-e:   Involved in methylation reactions, particularly in the liver, which are vital to numerous biochemical processes.*

SAM-e

The Multi-Functional Supernutrient
S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically proven to benefit brain, liver and joint function.* Found in all living cells, SAM-e is called “activated methionine”, formed by the combination of ATP and methionine. Methionine supplementation, however, does not elevate SAM-e. Rather, it elevates toxic homocysteine.

SAM-e has undergone many clinical trials involving thousands of patients. Researchers have identified many structure and functionbased benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, enhancing cartilage formation and lifting mood.*

Liver Detoxification
SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function. GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.*

Brain Function
SAM-e supports brain function by its methylation effects. Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donators in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism. Neurotransmitters, substances involved in nerve cell communication, are products of methylation. These compounds include L-dopa, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). There is a connection between SAM-e levels and cognitive health.* Conversely, increasing serotonin and dopamine levels contribute to brain health and improved mood.* SAM-e works quickly; many people feel the effects within a week.*

Energy Production
Methylation from SAM-e is critical for creatine production. Creatine metabolites are important for ADP to ATP recycling, and storing energy for immediate needs. Creatine maximizes physical performance, reduces exercise fatigue and improves recovery after exercise.*

Longevity
A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. Thismay contribute to declining health on many levels. Fortunately, these disturbances are often mitigated by SAMe supplemention.*

Methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.*

Healthy Connective Tissue
Research has shown that regular SAM-e supplementation helps improve joint health, and is used in Europe by physicians for the management of knee pain.*

Not All SAM-e is Created Equal
SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas® SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, and results in maximum blood levels.

• Essential for detoxification enzymes in the liver*
• The most important methyl-donating substance*
• Supports the production of healthy connective tissue*
• Blister packed for ultimate protection

Size: 60 Cap

Other Ingredients

Microcrystalline cellulose, mannitol, sodium starch glycolate, silicon dioxide, glycerol behenate, magnesium stearate (vegetable source), enteric coating (methacrylate copolymers), titanium dioxide, magnesium silicate, triethylcitrate, riboflavin, glycerol palmitostearate, and medium chain triglycerides.

Suitable for vegetarians/vegans.

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

This product complies with the proposed USP Monograph for SAM-e

PRODUCT OF ITALY.

Store in a cool, dry place.

Keep out of the reach of children

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.