Jarrow QH-absorb, CoQ10 (Ubiquinol), 200 mg, 30 Softgels

What does QH-absorb ® do?

PRODUCT HIGHLIGHTS

• Ubiquinol High Absorption Softgel
  • 3 Dosages: 30, 100, 200 mg
• “Active Antioxidant” Form of CoQ10
• Results in Higher Blood Levels Than CoQ10*
  • Especially for older consumers
• Q-Absorb® High-Absorption System
• Kaneka QH ™ Ubiquinol

Ubiquinol is the reduced (active antioxidant) state of Co-Q10, the form which is directly used in human metabolism as a lipid-soluble antioxidant. While standard Co-Q10 (ubiquinone) supplements can be activated in the body, this activation can be less efficient in some individuals, based on age, genetics, blood sugar status or level of oxidative stress.*

Jarrow FORMULAS QH-absorb is in an enhanced stability formula that utilizes the Q-absorb natural proliposome lipid-soluble delivery system, which has been clinically shown in humans to increase Co-Q10 levels up to 400% (3.2x) over baseline and is 3-4 times better absorbed than chewable Co-Q10 tablets.

Ubiquinol is derived from Co-Q10 that is manufactured via a yeast-fermentation process and consists only of the natural trans configuration, the same as is biosynthesized in the human body. Jarrow FORMULAS supports clinical research on Coenzyme Q10.

Who Can Benefit From this Product?

Designed for those who seek the superior absorption of ubiquinol for cardiovascular and antioxidant health. May be particularly useful to older consumers who may not activate CoQ10  sufficiently or whose levels have been depleted.*

What Distinguishes this Product?

• Active antioxidant (reduced) form of CoQ10 – ubiquinol
• Ubiquinol is significantly better absorbed than the traditional ubiquinone form of CoQ10
• Jarrow Formulas has 25+ years experience with CoQ10 products
• Synergistic bioavailability through pairing ubiquinol with the Q-absorb natural proliposomal delivery system

How Does Each Active Ingredient Function in this Product?

Ubiquinol:   The active ingredient in QH-absorb is an integral molecule in the body’s CoQ10 cycle, which is critical to generating cellular energy. It also acts as an important antioxidant in circulating LDL molecules and cell membranes protecting the body from oxidative stress.*

QH-absorb ®
Ubiquinones are a series of homologous molecules that possess a quinone active center and an unsaturated fatty tail. Ubiquinones are so named because they are widely distributed (i.e. ubiquitous) in nature and throughout the human body. Structurally they are very similar to the menaquinones, like vitamin K2. The quinone group acts as a courier for protons and electrons, which is the critical property that allows ubiquinones to act as antioxidants and as important intermediates in energy generation. The fatty tail is composed of isoprenoid  subunits, which are five carbon building blocks that help all living things biosynthesize critical components like immune modulators, essential oils and hormones. The number of isoprenoid units in the fatty tail is often denoted in the name of specific ubiquinones. For instance, unbiquinone-10 is made from ten isoprenoid units. Ubiquinone-10 (aka CoQ10, coenzyme Q10, Q) is more commonly referred to as just “ubiquinone.” This is because it is the most prevalent ubiquinone in almost all mammals, including humans.

What is Ubiquinol?
Ubiquinone and ubiquinol (aka ubiquinol-10, CoQ10-H2, QH, “reduced” CoQ10 ) are intimately related, as their names suggest. Inside the body, CoQ10 (ubiquinone) can only achieve its important functions in energy production, cardiovascular health and antioxidant protection with the help of ubiquinol.* In fact, all of the benefits that have been attributed to CoQ10 necessitate ubiquinol involvement. The two do their work by shuttling electrons and protons back-andforth, cyclically transforming from ubiquinone to ubiquinol and back again. In energy production, CoQ10 facilitates electron transfer within mitochondrial membranes to produce ATP, the body’s energy currency.* For antioxidant protection, ubiquinol is the “active antioxidant” form of CoQ10. This means that CoQ10 that has not been converted to ubiquinol is inactive as an antioxidant. Perhaps this explains why circa 80-95% of total CoQ10-ubiquinol exists as ubiquinol in the blood and in healthy tissues that require its antioxidant function.*

Is Taking Ubiquinol Better Than Taking CoQ10?
CoQ10 and ubiquinol are critically obtained from the diet, but it appears that absorption of CoQ10 may entail conversion to ubiquinol. This conversion occurs as early as in the enterocytes, the absorptive cells in the intestine, and may facilitate the absorption process. Also under normal conditions there are enzymes that help regenerate ubiquinol from spent CoQ10, in the body. Unfortunately, aging and illness can lead to both a reduced ability to regenerate ubiquinol because of decreased enzyme activity and a decreased ability to absorb CoQ10 itself, possibly for the same reason. A recent theory in nutrition science posits supplementing with endogenous nutrients, whose levels have decreased with age or illness, may upregulate the enzymes responsible for producing and using these nutrients in the body.

Ubiquinol is recommended for people who need it due to age or illness. After about age 45, total CoQ10 levels and ubiquinol levels in relation to CoQ10 tend to decline in various critical tissues. Some physicians have even started to use blood and tissue ratios of ubiquinol to CoQ10 as a biomarker for age- and illness-related oxidative stress. So taking ubiquinol can help overcome both problems of absorption and ubiquinol regeneration in the body. But where’s the evidence?

Clinical Studies and Comparison with CoQ10
In a study that compared daily intake of 100 mg of CoQ10 to 100 mg of ubiquinol, in rats, the ubiquinol group had a two-fold increase in total plasma CoQ10-ubiquinol compared to the CoQ10 group. Another study found that daily supplementation with 150 mg of ubiquinol, in humans, led to a 5.9 times increase of ubiquinol levels over baseline after 28 days. Anecdotal reports from practicing physicians also report that supplementing with ubiquinol directly (as opposed to CoQ10) allows plasma and tissue ubiquinol levels to be reached that just cannot be obtained with CoQ10.*

And let’s make sure not to forget the statin/CoQ10-ubiquinol connection. Popular cholesterol lowering drugs (statins) work by inhibiting an enzyme that is also responsible for CoQ10-ubiquinol biosynthesis. As a result, anyone taking statins may have reduced levels of CoQ10-ubiquinol; those over 45 who take statins may benefit from supplementing with ubiquinol directly rather than just CoQ10.*

Ubiquinol is Safe
Scientists have understood the value of ubiquinol for decades. It has just taken that long to figure out a way to stabilize ubiquinol so it can be formulated into a nutritional supplement product. Toxicity studies have shown little problem with taking ubiquinol directly, even at high doses. Plasma ubiquinol levels appear to plateau after two to four weeks of daily ingestion and then return near to baseline two weeks after daily ingestion is discontinued. It also appears that supplementation with ubiquinol does not reduce CoQ10 biosynthesis.

Jarrow Formulas QH-absorb is made with Ubiquinol, the more bioavailable, active-antioxidant form of CoQ10. It utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorption beyond that of ubiquinol alone.

Size: 30 Tabs

Other Ingredients

Medium chain triglycerides, phosphatidylcholine (from soy lecithin), beeswax, rosmarinic acid, vitamin E, and ascorbyl palmitate. Softgel consists of gelatin, glycerin and water. Carob and caramel extract added as a light barrier.

No wheat, no gluten, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts

Keep out of the reach of children

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.