Jarrow Bone-Up, 240 Tab

What does Bone-Up ® do?

PRODUCT HIGHLIGHTS

• Complete Multinutrient Bone-Health System
• Published Clinical Trial With Bone-Up ®
• Ossein Hydroxyapatite Complex
  • Source of natural bone-growth factors
• Often Imitated Bone Supplement
• Bone Up is always UP-FORMULATED ™ to include the latest breakthroughs in bone health

BONE-UP ® provides ossein hydroxyapatite complex (OHC) (from free-range Australian/New Zealand calves), which includes thesuperior combination of the inorganic calcium lattice of  microcrystalline hydroxyapatite (MCHA) within an organic protein milieu rich in naturally occurring growth factors. The OHC is combined with vitamin D3 and vitamin K2 as MK-7 (a more bioavailable form of vitamin K) to support the deposition of calcium into the bones as well as to assist in building up the organic bone matrix.* Potassium citrate is also added for optimal osteo support.* Also added are Magnesium, vitamin C, Zinc, Copper, Manganese & Boron.

HEALTH CLAIM: Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis later in life. For best results, use with Jarrow Formulas JarroSil ™, the biologically Activated Silicon ™.

Who Can Benefit from this Product?

Many people are not meeting the current recommendations for adequate calcium intake via diet or with supplement use. This product provides needed calcium, but also includes other essentials for proper calcium utilization by the body.

What Distinguishes this Product?

• Complete Multinutrient Bone-health System
• Published clinical trial with Bone-Up
• Ossein microcrystalline hydroxyapatite contains active bone-growth factors
• #1 Imitated Bone Supplement
• Bone Up is always UP-FORMULATED ™ to include the latest breakthroughs in bone health.

How Do the Active Ingredients Function in this Product?

Ossein Microcrystalline Hydroxyapatite (MCHA):   Produces more prolonged calcium balance than soluble calcium salts. Ossein MCHA provides both the inorganic constituents found in human bone and the organic bone growth factors that stimulate bone osteoblast cells.*

Vitamin D3 (1000 IU):   Converts to calcitriol, the active form of vitamin D3, in the kidneys. Calcitriol enhances calcium and phosphorous absorption and stimulates the synthesis of osteocalcin, an important structural protein in bone. Vitamin D3 is superior to vitamin D2, as it has been shown to raise blood levels 70% better than D2.*

Potassium:   Helps neutralize acidic physiological pH, which can adversely affect bone health. In maintaining the acid–alkaline balance in our bodies, potassium helps avoid unhealthy levels of calcium excretion in the urine.*

MK-7 (Menaquinone-7):   The more bioavailable form of vitamin K2. MK-7 remains in circulation much longer than vitamin K1 and is responsible for the carboxylation of specific bone proteins needed for building bone. MK-7 also discourages unwanted calcium deposition in arteries.*

Boron:    A trace mineral important in calcium and bone metabolism. Supplemental boron has been shown to reduce excretion of calcium, magnesium and phosphorus*

Manganese, Copper & Zinc:   Essential components of several enzymes involved in the formation of bone

Bone-Up ®

Jarrow Formulas ® Bone-Up ® is an most advanced and complete nutritional regimen for maintaining strong, healthy bones.* Bone Up has been a featured product of Jarrow Formulas for some time and has been updated through the years to reflect the latest scientific findings regarding skeletal health.

Natural Protectors
Bone-Up also includes vitamins C, D3 and K2 as MK-7. Inadequate levels of vitamin C and magnesium can promote over-calcification and breakdown of bone structure. Vitamin C helps form collagen, the connective tissue for strong and flexible, not brittle, bones.  Vitamin D is critical for calcium absorption. Vitamin K produces osteocalcin, a protein matrix upon which calcium crystallizes. Other major bone health nutrients included are Magnesium, Zinc, Manganese, Copper and Boron.*

Japanese Secret for Bone Health
Women in Japan have lower rates of hip fracture than women in theWest despite consuming far less calcium. Their secret is natto, from fermented soybeans, which is associated with significantly higher bone mineral density and fewer osteoporotic fractures.

Natto is a source of menaquinone-7 (MK-7), a special form of vitamin K2. A clinical study found that markers for hip fracture risk were decreased much more by K2 than by K1. The data suggest that K2, but not K1, decreases bone turnover (a strong risk factor for accelerated bone loss).*

Supporting Bone Matrix
Bone loss may be favorably influenced by MSM because the internal matrix of bone depends upon collagen webbing. Most of the body’s collagen protein is found in the bones, which is simply mineralized connective tissue. MSM provides a crucial nutrient needed for bone matrix.* Try Jarrow Formulas MSM Sulfer.

Preventing Bone Turnover
Osteoclasts break down bone tissue, while osteoblasts build bone. Though all tissues must be replaced regularly, excessive breakdown leads to bone thinning; this process increases with age. A variety of factors, including immune activity, tip the scales toward destruction. Inflammatory cytokines play a major role in bone breakdown. Curcumin, an anti-inflammatory pigment in turmeric traditionally associated with bone and joint health, was found to strongly inhibit osteoclast production.* Try adding Jarrow Formulas Curcumin to your diet.

Flax, another food associated with bone health, is by far the best source of lignans, plant fibers that bind toxins in the gut. Lignans are also phytoestrogens, plant compounds that weakly resemble sex hormones produced by both women and men. Phytoestrogens can either tone down excessive estrogen activity or bolster estrogenic activity when levels are low. They also compete with xenoestrogens, harmful estrogen-like molecules from pesticides, etc. Thus, phytoestrogens help protect us from environmental toxins. During menopause, lignans can weakly activate estrogen receptors and improve bone strength during times when estrogen levels are low.*

More Than Just Calcium
Several key minerals are offered in Bone Up. Magnesium, amineral deficient in most diets, helps keep calcium out of soft tissues (as does vitamin K2). Bone contains zinc and manganese, which help maintain the activity of joint tissue cells and osteoblasts. Copper is needed for bone development and healthy joints. The enzyme responsible for cross-linking collagen requires copper, which has been shown to substantially reduce bone loss in women. Boron plays a role in estrogen maintenance, and has been shown to reduce the urinary loses of calcium and magnesium.

• Calcium from 100% Ossein Microcrystalline Hydroxyapatite
• MK-7, Bio-Available Vitamin K to Support Bone Health
• Complete Supplement for Maintaining Bone Density*

Bone Mass and Hydroxyapatite
In 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fifty-three post-menopausal women diagnosed to have seriously impaired calcium absorption and accelerated bone loss were separated into three groups and studied for over 14 months. At the conclusion of the study, only the women that received 1,000 mg of calcium from hydroxyapatite along with vitamin D showed a significant increase in bone thickness.*

Hydroxyapatite produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue. Furthermore, hydroxyapatite provides both the organic and inorganic constituents found in human bone: hydroxyapatite microcrystals consist of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.*

Bone Health
Bone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility. Hydroxyapatite composes 67% of the weight of bone, and the collagenous fibers make up the remaining 33%.*

The average adult has 1,000 -1,200 grams of calcium in the body. Bones are the body’s largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable.

Between 2 - 4% of a person’s skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be “remodeled” or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost.

It has been estimated that post-menopausal women lose 0.7% to 2% of their bone per year while men lose 0.5%-0.7%. Between 45 and 75 years of age, women lose 30% of their skeletal structure and men lose 15%.

Calcium Plus
It starts with the finest source of calcium available: Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used). Skeletal health, however, requires more than calcium. Scientific evidence conclusively demonstrates the need for other nutrients like vitamin D3, vitamin K, potassium, magnesium, boron, and trace minerals such as zinc, copper, and manganese.*

Who Needs to Supplement Calcium?
Research has indicated that 85% of women over the age of 20 and at least 50% of men from age 35 consume less than the RDI for calcium. Caffeine, alcohol, sugar, chocolate, high protein diets and soda pops, particularly colas that are high in phosphorous can deplete calcium.

In addition, calcium absorption has long been thought to be stomachacid dependent, but both stomach acid production and calcium absorption decline with age.

Bone-Up Clinical Trial
The results of a recent clinical trial published in the Journal of Nutritional & Environmental Medicine (Disilvestro RA et al. J Nutr Environ Med. 2007; 16(1):26-32) found that exercise and supplementation of calcium, vitamin D3 and other micronutrients from Bone Up significantly improved bone health in young adult women.*

In an 8-week double-blind placebo-controlled study of 24 female students ages 18 to 24, supplementation with Bone Up (not placebo) was found to produce statistically significant decreases in markers of bone degradation, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OHvitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.*

Size: 60 Tabs

Suggested Usage
Take 1 to 6 capsules per day with meals, preferably dividing the number of capsules equally with each meal to facilitate maximum absorption, or as directed by your qualified health care consultant.

Health Claim
In conjunction with regular, weight-bearing exercise and a healthy diet, calcium helps teen and young adult women build bone mass and maintain bone health, and may reduce their risk of osteoporosis later in life.* Daily calcium intake above 2,000 mg is not likely to provide additional benefit. Adequate calcium intake is also linked to reduced osteoporosis by slowing bone loss in older men and women.*

Main Ingredients: Calcium, Vitamin D3, Magnesium, Vitamin C, Potassium, Vitamin K as MK-7, Zinc, Boron, copper & Manganese

Other Ingredients: Magnesium stearate (vegetable source) and silicon dioxide. Mineral amounts are elemental. Capsule consists of gelatin.

Contains: Soy.No wheat, no gluten, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Keep out of the reach of children

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.